Chromosomal Microarray (Prenatal)

Microarray

The genetic material of humans is packed into small units called chromosomes that have their own genetic combinations. The slightest change in the genetic combination of these chromosomes may be addition, deletion or duplication can result in birth defects, developmental delays, autism, and other health issues. The Chromosomal MicroArray is a high-resolution molecular genetic test that screens for such varied chromosomal DNA changes that may otherwise go undetected.

Advantages

Detects aneuploidy (including trisomy and sex chromosome abnormalities) & triploidy Identifies sub-microscopic deletions and duplications in regions known to be associa ted with well-characterized microdeletion & microduplication syndromes Pr ovides enriched c o verage of subtelomeric regions, often undetectable by traditional chromosome analysis More comprehensive and cost-effective than individual FISH tests Circum vents cell culture in most cases with more efficient turnaround times. Often allows for results on suboptimal specimens for which chromosome analysis is not feasible, SNP array allows detection of Triploidy, Uniparental disomy & LOH.

Limitation

The minimum resolution required for the reporting of Microarray RapidSure Optima (315K) is 1 MB for losses, 2 MB for gains, and 5 MB for LOH / AOH for Microarray RapidSure Optima (315K).

Advantages

Detects aneuploidy (including trisomy and sex chromosome abnormalities) & triploidy Identifies sub-microscopic deletions and duplications in regions known to be associa ted with well-characterized microdeletion & microduplication syndromes Pr ovides enriched c o verage of subtelomeric regions, often undetectable by traditional chromosome analysis More comprehensive and cost-effective than individual FISH tests Circum vents cell culture in most cases with more efficient turnaround times. Often allows for results on suboptimal specimens for which chromosome analysis is not feasible, SNP array allows detection of Triploidy, Uniparental disomy & LOH.

Limitation

The minimum resolution required for the reporting of Microarray RapidSure Deepdive (750K) is 200 KB for losses, 200 KB for gains, and 5 MB for LOH / AOH for Microarray RapidSure Deepdive (750K).

This test is exclusively for prenatal testing. It is upto the choice of a clinician to choose either Microarray Rapidsure Optima (315K) and Microarray Rapidsure Deepdive (750k)

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Accreditations

CLIA No. 34D2205781